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\insrsid15876614 \cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
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\par }}\pard\plain \ltrpar\qr \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 LOA No.:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 {\rtlch\fcs1 \af0 \ltrch\fcs0 \cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 LOA 1(10/08/2015)}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid1013805 {\*\nesttableprops\trowd \irow1\irowband1\lastrow \ltrrow
\ts11\trrh282\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid1013805\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrnone \clbrdrl\brdrnone \clbrdrb\brdrnone \clbrdrr
\brdrnone \cltxlrtb\clftsWidth3\clwWidth3249\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx3249\clvertalt\clbrdrt\brdrnone \clbrdrl\brdrnone \clbrdrb\brdrnone \clbrdrr\brdrnone 
\cltxlrtb\clftsWidth3\clwWidth3859\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx10340\nestrow}{\nonesttables
\par }\ltrrow}\trowd \irow0\irowband0\ltrrow\ts11\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl 
\clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth13575\clshdrawnil \cellx13575\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1647\clshdrawnil \cellx15222\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \cell 
}\pard\plain \ltrpar\s15\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs2\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid15876614 \cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \trowd \irow0\irowband0\ltrrow\ts11\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl 
\clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth13575\clshdrawnil \cellx13575\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1647\clshdrawnil \cellx15222\row 
\ltrrow}\trowd \irow1\irowband1\ltrrow\ts11\trrh180\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb
\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth13575\clshdrawnil \cellx13575\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1647\clshdrawnil \cellx15222\pard\plain \ltrpar
\s15\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs2\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \cell \cell 
}\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid15876614 \trowd \irow1\irowband1\ltrrow\ts11\trrh180\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl \clbrdrl
\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth13575\clshdrawnil \cellx13575\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1647\clshdrawnil \cellx15222\row 
}\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 Study Design:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid1013805 {\*\nesttableprops\trowd \irow0\irowband0\ltrrow\ts11\trrh282\trleft9\trbrdrt\brdrs\brdrw17\brdrcf1 \trbrdrl\brdrs\brdrw17\brdrcf1 \trbrdrb\brdrs\brdrw17\brdrcf1 \trbrdrr\brdrs\brdrw17\brdrcf1 
\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid1013805\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw17\brdrcf1 \clbrdrl\brdrs\brdrw17\brdrcf1 \clbrdrb\brdrnone \clbrdrr
\brdrs\brdrw17\brdrcf1 \cltxlrtb\clftsWidth3\clwWidth6787\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx6796\nestrow}{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 A5346 is a phase II, randomized, double-blinded, placebo-controlled trial of a DPP4 inhibitor (sitagliptin\hich\af1\dbch\af1\loch\f1 
; 100 mg/day) to determine whether sitagliptin reduces plasma sCD14 concentrations.\line \line 
The study population will include HIV-infected men and women >=18 years of age who are continuously treated with cART and have undetectable plasma viremia for the prior >\hich\af1\dbch\af1\loch\f1 =\hich\af1\dbch\af1\loch\f1  48 weeks. \line \line 
Participants will be stratified by screening CD4+T cell count and statin use and randomized 1:1 to 2 arms such that 43 participants will be enrolled in each arm. \line \line Arm 1: Sitagliptin (Januvia) 100 mg one tablet daily p.o. for 16 weeks, follow
\hich\af1\dbch\af1\loch\f1 e\hich\af1\dbch\af1\loch\f1 d by a 4-week post-treatment follow-up.\line \line Arm 2: Placebo for sitagliptin one tablet daily p.o. for 16 weeks, followed by a 4-week post-treatment follow-up.\line \line (Section 3.0)\line 
\line }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid1013805 {\*\nesttableprops\trowd \irow1\irowband1\ltrrow\ts11\trrh282\trleft9\trbrdrt\brdrs\brdrw17\brdrcf1 \trbrdrl\brdrs\brdrw17\brdrcf1 \trbrdrb\brdrs\brdrw17\brdrcf1 \trbrdrr\brdrs\brdrw17\brdrcf1 
\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid1013805\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrnone \clbrdrl\brdrs\brdrw17\brdrcf1 \clbrdrb\brdrnone \clbrdrr
\brdrs\brdrw17\brdrcf1 \cltxlrtb\clftsWidth3\clwWidth6787\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx6796\nestrow}{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid15876614 \nestcell{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid1013805 {\*\nesttableprops\trowd \irow2\irowband2\lastrow \ltrrow\ts11\trrh282\trleft9\trbrdrt\brdrs\brdrw17\brdrcf1 \trbrdrl\brdrs\brdrw17\brdrcf1 \trbrdrb\brdrs\brdrw17\brdrcf1 \trbrdrr\brdrs\brdrw17\brdrcf1 
\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid1013805\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrnone \clbrdrl\brdrs\brdrw17\brdrcf1 \clbrdrb\brdrs\brdrw17\brdrcf1 \clbrdrr
\brdrs\brdrw17\brdrcf1 \cltxlrtb\clftsWidth3\clwWidth6787\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx6796\nestrow}{\nonesttables
\par }\ltrrow}\trowd \irow2\irowband2\ltrrow\ts11\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl 
\clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth13575\clshdrawnil \cellx13575\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1647\clshdrawnil \cellx15222\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \cell 
}\pard\plain \ltrpar\s15\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs2\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid15876614 \cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \trowd \irow2\irowband2\ltrrow\ts11\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl 
\clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth13575\clshdrawnil \cellx13575\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1647\clshdrawnil \cellx15222\row 
}\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 Study Objectives:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }\nestcell{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid15876614 {\*\nesttableprops\trowd \irow0\irowband0\ltrrow\ts11\trrh282\trleft9\trbrdrt\brdrs\brdrw17\brdrcf1 \trbrdrl\brdrs\brdrw17\brdrcf1 \trbrdrb\brdrs\brdrw17\brdrcf1 \trbrdrr\brdrs\brdrw17\brdrcf1 
\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw17\brdrcf1 \clbrdrl\brdrs\brdrw17\brdrcf1 \clbrdrb\brdrnone \clbrdrr\brdrnone 
\cltxlrtb\clftsWidth3\clwWidth3163\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx3169\clvertalt\clbrdrt\brdrs\brdrw17\brdrcf1 \clbrdrl\brdrnone \clbrdrb\brdrnone \clbrdrr\brdrs\brdrw17\brdrcf1 
\cltxlrtb\clftsWidth3\clwWidth10411\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx13566\nestrow}{\nonesttables
\par }}\pard\plain \ltrpar\qr \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 Primary:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 {\rtlch\fcs1 \af0 \ltrch\fcs0 \cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 
To assess the effect of 16 weeks of sitagliptin 100 mg/day on plasma sCD14 concentrations.\line \line (Section 1.2) }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid15876614 {\*\nesttableprops\trowd \irow1\irowband1\ltrrow\ts11\trrh282\trleft9\trbrdrt\brdrs\brdrw17\brdrcf1 \trbrdrl\brdrs\brdrw17\brdrcf1 \trbrdrb\brdrs\brdrw17\brdrcf1 \trbrdrr\brdrs\brdrw17\brdrcf1 
\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrnone \clbrdrl\brdrs\brdrw17\brdrcf1 \clbrdrb\brdrnone \clbrdrr\brdrnone 
\cltxlrtb\clftsWidth3\clwWidth3163\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx3169\clvertalt\clbrdrt\brdrnone \clbrdrl\brdrnone \clbrdrb\brdrnone \clbrdrr\brdrs\brdrw17\brdrcf1 
\cltxlrtb\clftsWidth3\clwWidth10411\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx13566\nestrow}{\nonesttables
\par }}\pard\plain \ltrpar\qr \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 Secondary:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 {\rtlch\fcs1 \af0 \ltrch\fcs0 \cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 
1. To assess the effect of 16 weeks of sitagliptin 100 mg/day on plasma concentrations of \line \hich\af1\dbch\af1\loch\f1     CXCL10 (IP-10), sCD163, IL-6, sTNFR1 & 2, hs-CRP, and sCD26.\line \line 
2. To assess the effect of 16 weeks of sitagliptin 100 mg/day on the percentages of \line     CD4+CD38+HLA-DR+ and CD8+CD38+HLA-DR+ T-cell subpopulations.\line \line 3. To assess the effect of 16 weeks of\hich\af1\dbch\af1\loch\f1  
\hich\af1\dbch\af1\loch\f1 sitagliptin 100 mg/day on the percentages of \line     CD14+CD16- (classical), CD14+CD16+ (intermediate), and CD14dimCD16++ (non-\line     classical) monocyte subpopulations.\line \line 
4. To assess the effect of 16 weeks of sitagliptin 100 mg/day on the CD4+/CD8+ T-cell  \line  \hich\af1\dbch\af1\loch\f1  \hich\af1\dbch\af1\loch\f1   ratio.\line \line 
5. To assess the safety of 16 weeks of sitagliptin 100 mg/day in HIV-infected persons on \line     ART.\line \line 6. To assess the durability of the effect of sitagliptin 100 mg/day on plasma sCD14 \line 
    concentrations 4 weeks after discontinuing sitagliptin o\hich\af1\dbch\af1\loch\f1 r\hich\af1\dbch\af1\loch\f1  placebo (week 20). \line \line 7. To assess the durability of the effect of sitagliptin 100 mg/day on the percentages of \line 
    CD4+CD38+HLA-DR+ and CD8+CD38+HLA-DR+ T-cell subpopulations 4 weeks after  \line     discontinuing sitagliptin or placebo (week 20).\line \line 8. To ass\hich\af1\dbch\af1\loch\f1 e\hich\af1\dbch\af1\loch\f1 
ss the durability of the effect of sitagliptin 100 mg/day on the percentages of \line     CD14+CD16- (classical), CD14+CD16+ (intermediate), CD14dimCD16++ (non-\line 
    classical) monocyte subpopulations 4 weeks after discontinuing sitagliptin or placebo \line     (wee\hich\af1\dbch\af1\loch\f1 k\hich\af1\dbch\af1\loch\f1  20).\line \line 
9. To assess the durability of the effect of sitagliptin 100 mg/day on the CD4+/CD8+ T-\line     cell ratio 4 weeks after discontinuing sitagliptin or placebo (week 20).\line \line 
10. In the event that sitagliptin reduces plasma markers of immune activation or \line \hich\af1\dbch\af1\loch\f1  \hich\af1\dbch\af1\loch\f1      inflammation, we will assess the effect and durability of sitagliptin 100 mg/day on the \line 
      transcriptional activation of cell-associated HIV-1, the PBMC HIV-1 RNA/DNA ratio. \line \line 11. In the event that sitagliptin reduces plasma markers of immune act\hich\af1\dbch\af1\loch\f1 i\hich\af1\dbch\af1\loch\f1 vation or \line 
      inflammation, we will assess the effect and durability of sitagliptin 100 mg/day on \line       monocyte mRNA expression for pro-inflammatory cytokine and chemokine markers \line       (e.g., TLR-2, TLR-4, CCR2, and TNFalpha).\line \line 
(Section 1.3) }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid15876614 {\*\nesttableprops\trowd \irow2\irowband2\lastrow \ltrrow\ts11\trrh282\trleft9\trbrdrt\brdrs\brdrw17\brdrcf1 \trbrdrl\brdrs\brdrw17\brdrcf1 \trbrdrb\brdrs\brdrw17\brdrcf1 \trbrdrr\brdrs\brdrw17\brdrcf1 
\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrnone \clbrdrl\brdrs\brdrw17\brdrcf1 \clbrdrb\brdrs\brdrw17\brdrcf1 \clbrdrr\brdrnone 
\cltxlrtb\clftsWidth3\clwWidth3163\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx3169\clvertalt\clbrdrt\brdrnone \clbrdrl\brdrnone \clbrdrb\brdrs\brdrw17\brdrcf1 \clbrdrr\brdrs\brdrw17\brdrcf1 
\cltxlrtb\clftsWidth3\clwWidth10411\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx13566\nestrow}{\nonesttables
\par }\ltrrow}\trowd \irow3\irowband3\ltrrow\ts11\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl 
\clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth13575\clshdrawnil \cellx13575\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1647\clshdrawnil \cellx15222\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \cell 
}\pard\plain \ltrpar\s15\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs2\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid15876614 \cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \trowd \irow3\irowband3\ltrrow\ts11\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl 
\clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth13575\clshdrawnil \cellx13575\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1647\clshdrawnil \cellx15222\row 
}\pard\plain \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 Study Endpoints:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }\nestcell{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid1013805 {\*\nesttableprops\trowd \irow0\irowband0\ltrrow\ts11\trrh282\trleft9\trbrdrt\brdrs\brdrw17\brdrcf1 \trbrdrl\brdrs\brdrw17\brdrcf1 \trbrdrb\brdrs\brdrw17\brdrcf1 \trbrdrr\brdrs\brdrw17\brdrcf1 
\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid1013805\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrs\brdrw17\brdrcf1 \clbrdrl\brdrs\brdrw17\brdrcf1 \clbrdrb\brdrnone \clbrdrr
\brdrnone \cltxlrtb\clftsWidth3\clwWidth3184\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx3193\clvertalt\clbrdrt\brdrs\brdrw17\brdrcf1 \clbrdrl\brdrnone \clbrdrb\brdrnone \clbrdrr\brdrs\brdrw17\brdrcf1 
\cltxlrtb\clftsWidth3\clwWidth5195\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx8388\nestrow}{\nonesttables
\par }}\pard\plain \ltrpar\qr \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 Primary, Immunogenicity:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 {\rtlch\fcs1 \af0 \ltrch\fcs0 \cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 Change in sCD14 from baseline to week 16.
\line \line (Section 9.2.1) }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid1013805 {\*\nesttableprops\trowd \irow1\irowband1\ltrrow\ts11\trrh282\trleft9\trbrdrt\brdrs\brdrw17\brdrcf1 \trbrdrl\brdrs\brdrw17\brdrcf1 \trbrdrb\brdrs\brdrw17\brdrcf1 \trbrdrr\brdrs\brdrw17\brdrcf1 
\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid1013805\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrnone \clbrdrl\brdrs\brdrw17\brdrcf1 \clbrdrb\brdrnone \clbrdrr\brdrnone 
\cltxlrtb\clftsWidth3\clwWidth3184\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx3193\clvertalt\clbrdrt\brdrnone \clbrdrl\brdrnone \clbrdrb\brdrnone \clbrdrr\brdrs\brdrw17\brdrcf1 
\cltxlrtb\clftsWidth3\clwWidth5195\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx8388\nestrow}{\nonesttables
\par }}\pard\plain \ltrpar\qr \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\b\cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 Secondary, Immunogenicity:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \nestcell{\nonesttables
\par }}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap2 {\rtlch\fcs1 \af0 \ltrch\fcs0 \cf1\loch\af1\hich\af1\dbch\af1\insrsid15556642 \hich\af1\dbch\af1\loch\f1 
1 Change from baseline to week 16 in circulating levels of inflammatory \line    biomarkers CXCL10 (IP-10), sCD163, IL-6, sTNFR1 & 2, hs-CRP, sCD26.\line \line 2. Change from baseline to week 16 in the percentage and number of \line 
    CD4+CD38+HLA-DR+ and CD8+CD38+HLA-DR+ \hich\af1\dbch\af1\loch\f1 T\hich\af1\dbch\af1\loch\f1 -cell subpopulations\line \line 3. Change from baseline to week 16 in the percentages and number of \line 
    CD14+CD16- (classical), CD14+CD16+ (intermediate) and CD14dim \line     CD16++ (non-classical) monocyte subpopulations.\line \line 4. Change from baseline to week 16 in CD4+/C\hich\af1\dbch\af1\loch\f1 D\hich\af1\dbch\af1\loch\f1 8+ T-cell ratio.
\line \line 5. Occurrence of Grade >=3 AEs and selected Grade >=2 AEs related to \line     study drug.\line \line 6. Change from week 16 to week 20 for: plasma sCD14 levels, plasma \line 
    biomarker levels (CXCL10 (IP-10), sCD163, IL-6, sTNFR1 & 2, hs-CRP, \line     sCD26\hich\af1\dbch\af1\loch\f1 )\hich\af1\dbch\af1\loch\f1 , percentage and number of T-cell and monocyte subpopulations, \line     and CD4+/CD8+ T-cell ratio.\line \line 
7. In the event that sitagliptin reduces plasma markers of immune activation \line     or inflammation, change from baseline to week 16 and week 16 to week 20 \line    \hich\af1\dbch\af1\loch\f1  \hich\af1\dbch\af1\loch\f1 
in monocyte mRNA expression for pro-inflammatory cytokine or chemokine\line     markers (e.g., TLR-2, TLR-4, CCR2, TNFalpha).\line \line 8. In the event that sitagliptin reduces plasma markers of immune activation \line 
    or inflammation, change from baseline to week 16 an\hich\af1\dbch\af1\loch\f1 d\hich\af1\dbch\af1\loch\f1  week 16 to week 20 \line     in monocyte HIV RNA/DNA ratio.\line \line (Section 9.2.2) }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 
\nestcell{\nonesttables
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\ltrch\fcs0 \insrsid1013805 {\*\nesttableprops\trowd \irow2\irowband2\lastrow \ltrrow\ts11\trrh282\trleft9\trbrdrt\brdrs\brdrw17\brdrcf1 \trbrdrl\brdrs\brdrw17\brdrcf1 \trbrdrb\brdrs\brdrw17\brdrcf1 \trbrdrr\brdrs\brdrw17\brdrcf1 
\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tblrsid1013805\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrnone \clbrdrl\brdrs\brdrw17\brdrcf1 \clbrdrb\brdrs\brdrw17\brdrcf1 \clbrdrr
\brdrnone \cltxlrtb\clftsWidth3\clwWidth3184\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx3193\clvertalt\clbrdrt\brdrnone \clbrdrl\brdrnone \clbrdrb\brdrs\brdrw17\brdrcf1 \clbrdrr\brdrs\brdrw17\brdrcf1 
\cltxlrtb\clftsWidth3\clwWidth5195\clpadl39\clpadt39\clpadb39\clpadr39\clpadfl3\clpadft3\clpadfb3\clpadfr3\clshdrawnil \cellx8388\nestrow}{\nonesttables
\par }\ltrrow}\trowd \irow4\irowband4\lastrow \ltrrow\ts11\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb
\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth13575\clshdrawnil \cellx13575\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1647\clshdrawnil \cellx15222\pard\plain \ltrpar
\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \cell 
}\pard\plain \ltrpar\s15\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs2\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid15876614 \cell }\pard\plain \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 \trowd \irow4\irowband4\lastrow \ltrrow\ts11\trleft0\trftsWidth1\trftsWidthB3\trautofit1\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllkhdrcols\tbllknocolband\tblind0\tblindtype3 \clvertalt\clbrdrt
\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth13575\clshdrawnil \cellx13575\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1647\clshdrawnil \cellx15222
\row }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15876614 
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